Anticonvulsant intoxication precipitated by azapropazone.

Introduction Anticonvulsant drugs have a low therapeutic ratio so that dosage requirements are critical. Their effects are therefore susceptible to the influences of concurrent medication. In common with the anticonvulsants, the non-steroidal anti-inflammatory drugs tend to be highly protein bound and metabolized in the liver. Thus, potential for interaction between these groups of drugs exists. A case is reported in which such a hitherto unrecognized interaction led to serious toxicity.